The Skinny

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Detroit, Mi
I'm in the process. I'd like to expand on that, but it's in the process. I go about my business under the guidance of gut-feelings and universal street signs. I see myself as a very quiet person. Not because I have little to say, only that my abundant thoughts know not where to start. As a child I fantasized about looking through a telescope to give me truth about the world. It amuses me now that what I am doing is looking down a microscope in an effort to reevaluate my holistic position. I am a loner, a drifter, a dreamer.

Tuesday, September 23, 2008

God Particles

A thought. Just a thought. The misunderstanding people have regarding viruses. It's prevalent in fiction and pictures. Think of the number of times viruses have starred as the source of scifi stories. Writers run wild with the concept. From what I have gathered about viruses, not limited to what I have learned academically. Think of the word virus and what do you think? What do you think you know about these little non-living-but-kind-of-living creatures? It's all about the technicality when they made the decision that a virus is not considered sentinel although candidly it is animated. So what do I think based on the entirety of the noun?
I think viruses are the fingerprints of the tangible part of a higher power. They multiply and thrive without having to utilize much of anything. They act as a template that can insert into any other being, almost effortlessly, and manipulate it in ways that cascade into the uncharted future and beyond. They cannot be stopped. As mankind works tirelessly to eradicate the situation, the virus further taunts our mortality by exploiting it's corporal vessel at the cusp of discovering a magic bullet. Their minute size allows them to molest us according to their fancy. All we can do is be subjected.
The virus is not on top of the food chain, again, for technical reasons only. If we disregard the concurrence of the scientific clique, viruses dominate all living souls on earth. They are not limited to any specific plant or animal. On the contrary, they are specific for each plant, animal, and bacteria. They bring down the populations of ever kingdom of life, separate of each. They stand outside classification but govern taxonomy.
God is cited as the source of life. God is all mighty. God is steady in his resolve. So it is God's will to impart life, as it is to take life. Although unseen, God is in control of the whole stage. Not so different from our unseen little friends; our highly specialized, hyper efficient, indestructible, little God particles.

Sunday, September 14, 2008

Thalidomide Child

To illustrate the importance of chirality in modern society, we will examine the differences between the two enantiomers of the drug Thalidomide. Thalidomide was marketed in the 50’s and 60’s as a sedative to treat insomnia. German workers had revered this drug as the ideal hypnotic without noteworthy hazards or side effects. Consequently, in the early 60’s Thalidomide was distributed to a woman’s hospital to test for the effective treatment of morning sickness affiliated with pregnancy. Only later was it discovered that Thalidomide was a human teratogen. It was determined that the use of the drug by pregnant women could cause severe deformities of the limbs. The two isomers of Thalidomide show a remarkable range in the difference of effects after it is introduced to the body.
It’s amazing how the same molecule of a drug can show a profound effect when the only alteration is the spatial positioning of functional groups. In regards to Thalidomide, the sedative effects where exclusively reserved for the S-isomer. Conversely, the R-isomer was the culprit that impedes angiogenesis, consequently resulting in monstrous malformations. Unbeknownst at the time, the trade off for having a pleasant pregnancy was to have children born with anywhere from reduced or fused limbs to a Cyclops and Siamese twins.
It was also found that certain types of malformations where more prevalent in specific ethnicities due to the chirality. Different ethnicities of people metabolize chemicals at differing rates, so what may apply to one ethnic group may not apply to another. However it is still unclear what the exact mechanism of Thalidomide is. Nevertheless, what is known suggest that Thalidomide inserts into DNA at guanine sites accordingly changing the final proteins. The chirality of Thalidomide makes this molecule’s interaction with the enzymes very obnoxiously apparent in the many communities it encounters.
However, the S-isomer has a variety of other functions, many of which are still being explored. With the correct precautions, Thalidomide can be used therapeutically to treat the symptoms of other diseases. Thalidomide’s effective anti-inflammatory agent has made it a good contender in treating patients suffering from leprosy. In addition to treating leprosy, Thalidomide is also a known antiangiogenic and immunomodulatory mediator for cancer patients. It can also inhibit the growth of the HIV virus in vitro! Seemingly, from the S-isomer perspective, Thalidomide could function as a “wonder” drug.
Thalidomide has one chiral center and comes as a racemic mixture. Thalidomide’s two enantiomers can also undergo inversion into each other. It was seen that the rates of inversion increased with pH over the range of 7.0 - 7.5. In an in vitro experiment carried out by Eriksson, his findings supported the belief that chiral inversions take place primarily in the blood. Knowing the various affects that Thalidomide can have once taken it is important for drug companies to be able to distinguish between the two enantiomers.
From the perspective of the author who insists on manufacturing progeny one day, it is terrifying to consider the possibility of delivering an unhealthy child. It is emotionally taxing to know that your child may not have as high of a chance at survival outside the womb because of something you did. Since it seems that drugs have taken over America, it is vital to our existence and mental faculty that we regulate what is being shelved on the market. Something so seemingly minute at such a small scale could manifest into such a collection of sometimes horrendous outcomes, it is in our best interest to dedicate some energy into a comprehensive understanding of what we are meddling with.

Friday, September 12, 2008

Fuck me running

Oi. Life is so hectic. I'd like to say currently, but the case seems to be my life is constantly hectic. There is never any peace and quiet for me any longer. These obligations I have towards my family sometimes drive me insane. Why is it my job to lecture my mother on how to be matronly? Times like this, I just want to puke. I just want to cry. I want to throw a fit and die in a puddle of my own grief. I am not fit to hold the world on my shoulders, but the world seems to think I am capable of that if I get down on my knee. It hurts and I am exhausted now.
In an effort to organize what I call my life, I made a rudimentary web. The exact one I learned how to make in second grade. I even used a red marker. From this bubble labeled ME, are other boxes and shapes thrusting out from it; family, school, work, extra. curr. I wonder how I am to juggle all this shit. I work 2 jobs, am on the executive board for 2 organizations, I have 6 classes, and still have to do research. Looks like somethings got to go. I need to quit my cafe job. Focus it all in the lab. I just need to breath and I can't right now.
I'm worried about my dad. He needs health care and God help me I will smite anyone who thinks they can fuck with my family. Nothing gets me more worked up then my people who try fucking family. I have to act like the wife and mother. Now that my sister is gone, I have nobody to help me with this orchestrating. I need a new phone if I'm going to conduct business efficiently. Then again, my Buddhist principles teach me to go without. I'm choking. My mother is utterly useless. She throws money at me, but money can't buy my piece of mind. I still have to take care of my brother. It's stupid. He no longer even listens to my mother and disrespects my father. I have to be the sister and the executioner. He answers to me because he knows I don't fuck around and I will fucking use his eye sockets as ashtrays. I wish this would all just be over and that my dad is healthy. I hate my family because I love them so much.
The end of the year is drawing near. I say this and it's only the 9th month, but soon a paper will be due atop of all my other course work. I really need to quit midtown. I need to balance my checkbook and reclaim my time. Working at the cafe is not worth it. I only get paid 8 an hour and for the entire time I have to deflect lame come-ons by my coworker. It's a fucking shitshow. The only job that I care about is not paying me right now. Although that is the case, I'm just going to have to be more thrifty. I made up my mind. I'm not wasting my time at Midtown - I'll hustle for some extra cash, but I'm not putting in my time for it.
I have to get myself into see the dentist. I've put off getting cavities filled for at least a year now. So many loops to jump through, I'm bogged down with lactic acid. My mind is all a flutter because every aspect of my life demands so much of me. Fuck this, fuck this, and fuck you. I am about to fucking blow the fuck up in this bitch.
Still, I need to hold it together. I need to paint this perfect picture of my life because that is what society as deemed acceptable. I'm on the E-board for APO and the student rep for the Clinical Laboratory Science program. All this will look good on a resume and so it must be done. Even if I don't make it out of this academic war zone with all my limbs. I need to keep on moving. Life does not care and so, neither should I.